genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Research has uncovered certain genetic mutations (or changes) that likely play a role in the development of IgA nephropathy. —Cristina Mutchler, Health, 30 Sep. 2024

This approach mirrors successful models, such as a recent study in England that identified a unique genetic mutation in a local population, leading to targeted screening protocols. —Melissa Noel, Essence, 16 Sep. 2024

This discrepancy surprised us because the genetic mutation that causes melanism occurs less frequently than the one that causes albinism/leucism. —Elizabeth Carlen, Discover Magazine, 31 Oct. 2024

The cause behind developing multiple penises is generally believed to stem from genetic mutations affecting androgen receptors during development. —Andrew Paul, Popular Science, 16 Oct. 2024

Word History

First Known Use

1915, in the meaning defined above

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper